Suspensions of both vehicles were stable at room temperature and under refrigeration for 10 days.Īmoxicillin is a broad-spectrum, penicillin-based antibiotic that binds to penicillin-binding-proteins (PBP) to inhibit cell wall synthesis. The stability parameters examined were pH, concentration using high-performance liquid chromatography (HPLC), odor, suspendability, and appearance for 10 days. The suspensions were stored in PET plastic bottles under refrigeration and at room temperature for stability testing. Amoxicillin 500 mg capsules were mixed in a vehicle of Ora-Plus and Ora-Sweet (1:1), as well as an Ora-Plus/Ora-Sweet vehicle alkalinized with sodium hydroxide 20% (w/v) solution to a pH of 6. The primary objective of the study is to compound amoxicillin 400 mg per 5 mL oral suspension using 2 formulations.
0 Comments
Leave a Reply. |